Toll-like receptor 4 contributes to poor outcome after intracerebral hemorrhage
نویسندگان
چکیده
منابع مشابه
Toll-like receptor 4 contributes to retinal ischemia/reperfusion injury
PURPOSE We investigated whether retinal ischemia and inflammation produced by raising the intraocular pressure above normal systolic levels differs in mice that lack a functional toll-like receptor 4 (Tlr4) signaling pathway. METHODS In this work we used the murine strain B6.B10ScN-Tlr4(lps-del)/JthJ, which does not express functional Tlr4. C57BL/6J was considered as the control. We induced r...
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Toll-like receptor 4 (TLR4) activation mediates renal injury in regional ischemia and reperfusion (I/R) models generated by clamping renal pedicles. However, it remains unclear whether TLR4 is causal in the kidney injury following global I/R induced by cardiac arrest (CA) and cardiopulmonary resuscitation (CPR). The present study used wild‑type (C3H/HeN) and TLR4‑mutant (C3H/HeJ) mice to produc...
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INTRODUCTION Blend sign has been recently described as a novel imaging marker that predicts hematoma expansion. The purpose of our study was to investigate the prognostic value of CT blend sign in patients with ICH. OBJECTIVES AND METHODS Patients with intracerebral hemorrhage who underwent baseline CT scan within 6 hours were included. The presence of blend sign on admission nonenhanced CT w...
متن کاملIntracerebral hemorrhage volume predicts poor neurologic outcome in children.
BACKGROUND AND PURPOSE Although intracerebral hemorrhage (ICH) volume and location are important predictors of outcome in adults, few data exist in children. METHODS A consecutive cohort of children, including full-term newborns to those younger than 18 years of age with nontraumatic, acute ICH and head CT available for analysis were studied. Clinical information was abstracted via chart revi...
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OBJECTIVE Examine the relationship between anemia and outcomes from intracerebral hemorrhage (ICH). METHODS Patients admitted with spontaneous ICH between July 2008 and December 2010 were identified from our prospective stroke registry. Patients were divided into two groups based on admission hemoglobin (low vs. normal based on laboratory reference range for gender). Baseline characteristics ...
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ژورنال
عنوان ژورنال: Annals of Neurology
سال: 2011
ISSN: 0364-5134
DOI: 10.1002/ana.22528